Journal article
Modulation of poly(ADP-ribose) polymerase during neutrophilic and monocytic differentiation of promyelocytic (NB4) and myelocytic (HL-60) leukaemia cells
Abstract
Poly(ADP-ribose) polymerase (PARP) is a nuclear enzyme which has been shown to play a role in the differentiation of haematopoietic cells. We report here that neutrophils are the first nucleated mammalian cell type demonstrated to be devoid of immunoreactive PARP. Both NB4 acute promyelocytic leukaemia and HL-60 (acute myelocytic leukaemia) cells were differentiated into non-malignant neutrophils with all-trans-retinoic acid (ATRA). Western …
Authors
Bhatia M; Kirkland JB; Meckling-Gill KA
Journal
Biochemical Journal, Vol. 308, No. 1, pp. 131–137
Publisher
Portland Press
Publication Date
May 15, 1995
DOI
10.1042/bj3080131
ISSN
0264-6021