Journal article
Mapping the interaction surface of scorpion β-toxins with an insect sodium channel
Abstract
The interaction of insect-selective scorpion depressant β-toxins (LqhIT2 and Lqh-dprIT3 from Leiurus quinquestriatus hebraeus) with the Blattella germanica sodium channel, BgNav1-1a, was investigated using site-directed mutagenesis, electrophysiological analyses, and structural modeling. Focusing on the pharmacologically defined binding site-4 of scorpion β-toxins at the voltage-sensing domain II (VSD-II), we found that charge neutralization of …
Authors
Zhorov BS; Du Y; Song W; Luo N; Gordon D; Gurevitz M; Dong K
Journal
Biochemical Journal, Vol. 478, No. 14, pp. 2843–2869
Publisher
Portland Press
Publication Date
July 30, 2021
DOI
10.1042/bcj20210336
ISSN
0264-6021