Conference
Epigenetic Repression of the Adaptor Molecule LAT2 by the Leukemic Fusion Protein AML1/ETO.
Abstract
Abstract
The chromosomal translocation (8;21) fuses the hematopoietic transcription factor AML1 (RUNX1) with ETO, resulting in the leukemia-specific chimeric protein AML1/ETO. This fusion protein represses transcription by recruiting a nuclear co-repressor complex containing HDACs and DNMT1 to its target promoters. Previously, we have identified a novel in vivo AML1/ETO target gene, LAT2 (NTAL/LAB/WBSCR5), which is involved in …
Authors
Duque-Afonso J; Berg T; Heidenreich O; Luebbert M
Volume
110
Publisher
American Society of Hematology
Publication Date
November 16, 2007
DOI
10.1182/blood.v110.11.987.987
Conference proceedings
Blood
Issue
11
ISSN
0006-4971