LSD1 Inhibition Induces Differentiation and Reduces the Frequency of Leukemia-Initiating Cells in Hoxa9/Meis1-Induced Acute Myeloid Leukemia

Abstract The histone demethylating enzyme LSD1 has emerged as a promising epigenetic target in the treatment of acute myeloid leukemia (AML). Inhibition of LSD1 has been shown to induce differentiation and facilitate the responsiveness of AML cells to all-trans retinoic acid (ATRA). As it remains unclear how LSD1 inhibition induces differentiation, we have now used a murine leukemia model based on retroviral overexpression of …