Journal article
Nonhematopoietic cells represent a more rational target of in vivo hedgehog signaling affecting normal or acute myeloid leukemia progenitors
Abstract
Recent work has shown that leukemic stem cell self-renewal in chronic myeloid leukemia is dependent on cell-intrinsic hedgehog (Hh) signaling, and early clinical trials suggest that targeting this pathway is also therapeutic in patients with acute myeloid leukemia (AML). In this study, we aimed to better understand Hh signaling in normal hematopoiesis and AML by molecularly and functionally analyzing more than 200 primary human AML patient …
Authors
Boyd AL; Salci KR; Shapovalova Z; McIntyre BAS; Bhatia M
Journal
Experimental Hematology, Vol. 41, No. 10, pp. 858–869.e4
Publisher
Elsevier
Publication Date
10 2013
DOI
10.1016/j.exphem.2013.05.287
ISSN
0301-472X