Journal article
Niche displacement of human leukemic stem cells uniquely allows their competitive replacement with healthy HSPCs
Abstract
Allogeneic hematopoietic stem cell (HSC) transplantation (HSCT) is currently the leading strategy to manage acute myeloid leukemia (AML). However, treatment-related morbidity limits the patient generalizability of HSCT use, and the survival of leukemic stem cells (LSCs) within protective areas of the bone marrow (BM) continues to lead to high relapse rates. Despite growing appreciation for the significance of the LSC microenvironment, it has …
Authors
Boyd AL; Campbell CJV; Hopkins CI; Fiebig-Comyn A; Russell J; Ulemek J; Foley R; Leber B; Xenocostas A; Collins TJ
Journal
Journal of Experimental Medicine, Vol. 211, No. 10, pp. 1925–1935
Publisher
Rockefeller University Press
Publication Date
September 22, 2014
DOI
10.1084/jem.20140131
ISSN
0022-1007