Journal article
Intrathecal Immunoglobulin M Synthesis is an Independent Biomarker for Higher Disease Activity and Severity in Multiple Sclerosis
Abstract
OBJECTIVE: We aimed to determine in relapsing multiple sclerosis (MS) whether intrathecal synthesis of immunoglobulin (Ig) M and IgG is associated with outcomes reflecting inflammatory activity and chronic worsening.
METHODS: We compared cerebrospinal fluid analysis, clinical and magnetic resonance imaging data, and serum neurofilament light chain (sNfL) levels at baseline and follow-up in 530 patients with relapsing MS. Patients were …
Authors
Oechtering J; Schaedelin S; Benkert P; Müller S; Achtnichts L; Vehoff J; Disanto G; Findling O; Fischer‐Barnicol B; Orleth A
Journal
Annals of Neurology, Vol. 90, No. 3, pp. 477–489
Publisher
Wiley
Publication Date
9 2021
DOI
10.1002/ana.26137
ISSN
0364-5134