Journal article
Age-related expression of prominent regulatory elements in mouse brain: catastrophic decline of FOXO3a
Abstract
Aging is associated with changes in regulation, particularly among diverse regulators in the brain. We assayed prominent regulatory elements in mouse brain to explore their relationship to one another, stress, and aging. Notably, unphosphorylated (activated) forkhead transcription factor 3a (uFOXO3a) expressed exponential decline congruent with increasing age-related mortality. Decline in uFOXO3a would impact homeostasis, aging rate, stress …
Authors
Rollo CD; Marsh-Rollo SE; Boreham D; Lemon JA
Journal
GeroScience, Vol. 43, No. 4, pp. 1935–1946
Publisher
Springer Nature
Publication Date
August 2021
DOI
10.1007/s11357-021-00364-8
ISSN
2509-2715