Journal article
Fibrotic extracellular matrix induces release of extracellular vesicles with pro-fibrotic miRNA from fibrocytes
Abstract
RATIONALE: Extracellular vesicles (EVs) are small lipid vesicles, and EV-coupled microRNAs (miRNAs) are important modulators of biological processes. Fibrocytes are circulating bone marrow-derived cells that migrate into the injured lungs and contribute to fibrogenesis. The question of whether EV-coupled miRNAs derived from fibrocytes are able to regulate pulmonary fibrosis has not been addressed yet.
METHODS: Pulmonary fibrosis was induced in …
Authors
Sato S; Chong SG; Upagupta C; Yanagihara T; Saito T; Shimbori C; Bellaye P-S; Nishioka Y; Kolb MR
Journal
Thorax, Vol. 76, No. 9, pp. 895–906
Publisher
BMJ
Publication Date
9 2021
DOI
10.1136/thoraxjnl-2020-215962
ISSN
0040-6376