Journal article
Crystallographic analysis of TarI and TarJ, a cytidylyltransferase and reductase pair for CDP-ribitol synthesis in Staphylococcus aureus wall teichoic acid biogenesis
Abstract
The cell wall of many pathogenic Gram-positive bacteria contains ribitol-phosphate wall teichoic acid (WTA), a polymer that is linked to virulence and regulation of essential physiological processes including cell division. CDP-ribitol, the activated precursor for ribitol-phosphate polymerization, is synthesized by a cytidylyltransferase and reductase pair known as TarI and TarJ, respectively. In this study, we present crystal structures of …
Authors
Li FKK; Gale RT; Petrotchenko EV; Borchers CH; Brown ED; Strynadka NCJ
Journal
Journal of Structural Biology, Vol. 213, No. 2,
Publisher
Elsevier
Publication Date
6 2021
DOI
10.1016/j.jsb.2021.107733
ISSN
1047-8477