Journal article
Aging and Interferons: Impacts on Inflammation and Viral Disease Outcomes
Abstract
As highlighted by the COVID-19 global pandemic, elderly individuals comprise the majority of cases of severe viral infection outcomes and death. A combined inability to control viral replication and exacerbated inflammatory immune activation in elderly patients causes irreparable immune-mediated tissue pathology in response to infection. Key to these responses are type I, II, and III interferons (IFNs), which are involved in inducing an …
Authors
Feng E; Balint E; Poznanski SM; Ashkar AA; Loeb M
Journal
Cells, Vol. 10, No. 3,
Publisher
MDPI
DOI
10.3390/cells10030708
ISSN
2073-4409