Journal article
Chronic Embryo‐Larval Exposure of Fathead Minnows to the Pharmaceutical Drug Metformin: Survival, Growth, and Microbiome Responses
Abstract
Metformin is a glucose-lowering drug commonly found in municipal wastewater effluents (MWWEs). The present study investigated the chronic effects of metformin in early-life stages of the fathead minnow (Pimephales promelas). Endpoints assessed were growth, survival, and deformities. The larval gut microbiome was also examined using 16 S ribosomal RNA gene amplicon sequencing to determine microbial community composition and alpha and beta …
Authors
Parrott JL; Restivo VE; Kidd KA; Zhu J; Shires K; Clarence S; Khan H; Sullivan C; Pacepavicius G; Alaee M
Journal
Environmental Toxicology and Chemistry, Vol. 41, No. 3, pp. 635–647
Publisher
Oxford University Press (OUP)
Publication Date
March 1, 2022
DOI
10.1002/etc.5054
ISSN
0730-7268