Journal article
Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA.
Abstract
Vancomycin resistance in Enterococcus faecium BM4147 is mediated by vancomycin resistance proteins VanA and VanH. VanA is a D-alanine:D-alanine ligase of altered substrate specificity [Bugg, T. D. H., Dutka-Malen, S., Arthur, M., Courvalin, P., & Walsh, C. T. (1991) Biochemistry 30, 2017-2021], while the sequence of VanH is related to those of alpha-keto acid dehydrogenases [Arthur, M., Molinas, C., Dutka-Malen, S., & Courvalin, P. (1991) Gene …
Authors
Bugg TD; Wright GD; Dutka-Malen S; Arthur M; Courvalin P; Walsh CT
Journal
Biochemistry, Vol. 30, No. 43, pp. 10408–10415
Publisher
American Chemical Society (ACS)
Publication Date
October 1, 1991
DOI
10.1021/bi00107a007
ISSN
0006-2960