Journal article
Synthesis and evaluation of photoaffinity probes directed at lanosterol 14α-demethylase (P-45014DM)
Abstract
A series of aromatic azides which could act as potential photoaffinity probes for the yeast lanosterol 14α-demethylase (P-45014DM) were prepared. One of these, 1-[3H]-p-azidophenyl-2-(1-imidazolyl)ethanol, has been demonstrated to label purified P-45014DM from Saccharomyces cerevisiae. These results provide the framework for future labeling experiments.
Authors
Wright GD; Honek JF
Journal
Bioorganic & Medicinal Chemistry Letters, Vol. 2, No. 5, pp. 383–386
Publisher
Elsevier
Publication Date
January 1992
DOI
10.1016/s0960-894x(00)80151-1
ISSN
0960-894X