Journal article
DNA methylation predicts age and provides insight into exceptional longevity of bats
Abstract
Exceptionally long-lived species, including many bats, rarely show overt signs of aging, making it difficult to determine why species differ in lifespan. Here, we use DNA methylation (DNAm) profiles from 712 known-age bats, representing 26 species, to identify epigenetic changes associated with age and longevity. We demonstrate that DNAm accurately predicts chronological age. Across species, longevity is negatively associated with the rate of …
Authors
Wilkinson GS; Adams DM; Haghani A; Lu AT; Zoller J; Breeze CE; Arnold BD; Ball HC; Carter GG; Cooper LN
Journal
Nature Communications, Vol. 12, No. 1,
Publisher
Springer Nature
DOI
10.1038/s41467-021-21900-2
ISSN
2041-1723