Journal article
The influence of therapy on CD4+CD25highFOXP3+ regulatory T cells in systemic lupus erythematosus patients: a prospective study
Abstract
OBJECTIVES: Regulatory T cells (Tregs) are inversely correlated to disease activity in systemic lupus erythematosus (SLE). However, little is known concerning the influence of immunosuppressive agents on Tregs, which was the objective of this study.
METHOD: Thirty-five patients with SLE (29 females, six males, mean age 42.4 ± 12.8 years) were included. CD4+CD25(high)FOXP3+ Tregs were prospectively assessed by flow cytometry every month for …
Authors
Tselios K; Sarantopoulos A; Gkougkourelas I; Boura P
Journal
Scandinavian Journal of Rheumatology, Vol. 44, No. 1, pp. 29–35
Publisher
Taylor & Francis
Publication Date
January 2, 2015
DOI
10.3109/03009742.2014.922214
ISSN
0300-9742
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdultAzathioprineCD4 AntigensCyclophosphamideFemaleFlow CytometryForkhead Transcription FactorsHumansHydroxychloroquineImmunoglobulins, IntravenousImmunosuppressive AgentsInterleukin-2 Receptor alpha SubunitLupus Erythematosus, SystemicMaleMethylprednisoloneMiddle AgedProspective StudiesPulse Therapy, DrugRemission InductionT-Lymphocytes, Regulatory