Journal article
Interleukin-15 is required for maximal lipopolysaccharide-induced abortion
Abstract
The maternal immune response during pregnancy is critical for the survival of the fetus yet can be detrimental during infection and inflammation. Previously, IL-15 has been observed to mediate inflammation during LPS-induced sepsis. Therefore, we sought to determine whether IL-15 mediates the inflammatory process during LPS-induced abortion through the use of IL-15(-/-) and WT mice. Administration of 2.5 μg LPS i.p. on gd 7.5 drastically …
Authors
Lee AJ; Kandiah N; Karimi K; Clark DA; Ashkar AA
Journal
Journal of Leukocyte Biology, Vol. 93, No. 6, pp. 905–912
Publisher
Oxford University Press (OUP)
Publication Date
March 15, 2013
DOI
10.1189/jlb.0912442
ISSN
0741-5400