Journal article
Type I interferon signalling is not required for the induction of endotoxin tolerance
Abstract
Endotoxin, or LPS tolerance, is an immunomodulatory mechanism that results in a significantly diminished response to secondary LPS exposure, which may serve to protect the host against endotoxic shock. Type I interferons (IFNs) are cytokines released upon LPS binding to TLR4 and have been shown to have immunomodulatory properties. Due to this regulatory function of type I IFN, we aimed to investigate the role of type I IFN signalling in LPS …
Authors
Karimi Y; Poznanski SM; Vahedi F; Chen B; Chew MV; Lee AJ; Ashkar AA
Journal
Cytokine, Vol. 95, , pp. 7–11
Publisher
Elsevier
Publication Date
July 2017
DOI
10.1016/j.cyto.2017.01.017
ISSN
1043-4666