99mTc-Functionalized Single-Walled Carbon Nanotubes for Bone Targeting

Tailoring carbon nanotube surface chemistry is essential for biomedical applications. Bisphosphonate–carbon nanotube conjugates were prepared to target regions of active bone metabolism. The conjugates were synthesized using covalent functionalization (G1) or latently reactive polymer–nanotube complexes (G2), and it was found that the noncovalent G2 method afforded higher quality colloidal dispersions. The in vitro cytotoxicity tests against …