Cationic, Anionic, and Amphoteric Dual pH/Temperature-Responsive Degradable Microgels via Self-Assembly of Functionalized Oligomeric Precursor Polymers

Multiresponsive smart materials with the capacity to reversibly change properties (i.e., size, charge) upon the application of more than one stimulus (i.e., temperature, pH) offer potential in numerous biotechnology and biomedical applications. However, their typical lack of degradability limits their potential in vivo use. Herein, we demonstrate the use of an aqueous thermally driven self-assembly approach based on hydrazide- and …