Interrupting reactivation of immunologic memory diverts the allergic response and prevents anaphylaxis

BACKGROUND: IgE production against innocuous food antigens can result in anaphylaxis, a severe life-threatening consequence of allergic reactions. The maintenance of IgE immunity is primarily facilitated by IgG⁺ memory B cells, as IgE⁺ memory B cells and IgE⁺ plasma cells are extremely scarce and short-lived, respectively. OBJECTIVE: Our aim was to investigate the critical requirements for an IgE recall response in peanut allergy.