Journal article
Targeting endothelin 1 receptor-miR-200b/c-ZEB1 circuitry blunts metastatic progression in ovarian cancer
Abstract
Identification of regulatory mechanisms underlying the poor prognosis of ovarian cancer is necessary for diagnostic and therapeutic implications. Here we show that endothelin A receptor (ETAR) and ZEB1 expression is upregulated in mesenchymal ovarian cancer and correlates with poor prognosis. Notably, the expression of ETAR and ZEB1 negatively correlates with miR-200b/c. These miRNAs, besides targeting ZEB1, impair ETAR expression through the …
Authors
Sestito R; Cianfrocca R; Tocci P; Rosanò L; Sacconi A; Blandino G; Bagnato A
Journal
Communications Biology, Vol. 3, No. 1,
Publisher
Springer Nature
DOI
10.1038/s42003-020-01404-3
ISSN
2399-3642
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsAntineoplastic AgentsCell Line, TumorDrug Delivery SystemsEndothelin A Receptor AntagonistsFemaleGene Expression Regulation, NeoplasticHumansMiceMice, NudeMicroRNAsNeoplasm MetastasisNeoplasms, ExperimentalOvarian NeoplasmsPyrimidinesReceptor, Endothelin ASulfonamidesZinc Finger E-box-Binding Homeobox 1