Journal article
Effects of lifelong testosterone exposure on health and disease: a Mendelian randomization study
Abstract
Testosterone products are prescribed to males for a variety of possible health benefits, but causal effects are unclear. Evidence from randomized trials are difficult to obtain, particularly regarding effects on long-term or rare outcomes. Mendelian randomization analyses were performed to infer phenome-wide effects of free testosterone on 461 outcomes in 161,268 males from the UK Biobank study. Lifelong increased free testosterone had …
Authors
Mohammadi-Shemirani P; Chong M; Pigeyre M; Morton RW; Gerstein HC; Paré G
Journal
eLife, Vol. 9, ,
Publisher
eLife
DOI
10.7554/elife.58914
ISSN
2050-084X