Journal article
A Robust and High Throughput Method for Anionic Metabolite Profiling: Preventing Polyimide Aminolysis and Capillary Breakages under Alkaline Conditions in CE-MS
Abstract
Capillary electrophoresis-mass spectrometry (CE-MS) represents a high efficiency microscale separation platform for untargeted profiling of polar/ionic metabolites that is ideal for volume-restricted biological specimens with minimal sample workup. Despite these advantages, the long-term stability of CE-MS remains a major obstacle hampering its widespread application in metabolomics notably for routine analysis of anionic metabolites under …
Authors
Yamamoto M; Ly R; Gill B; Zhu Y; Moran-Mirabal J; Britz-McKibbin P
Journal
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Publisher
ACS Publications
Publication Date
2016