Journal article
Neuroprotective Effect of Subdural Infusion of Serp-1 in Spinal Cord Trauma
Abstract
Spinal cord injury (SCI) initiates a severe, destructive inflammation with pro-inflammatory, CD68+/CD163-, phagocytic macrophages infiltrating the area of necrosis and hemorrhage by day 3 and persisting for the next 16 weeks. Inhibition of macrophage infiltration of the site of necrosis that is converted into a cavity of injury (COI) during the first week post-SCI, should limit inflammatory damage, shorten its duration and result in …
Authors
Kwiecien JM; Dabrowski W; Kwiecien-Delaney BJ; Kwiecien-Delaney CJ; Siwicka-Gieroba D; Yaron JR; Zhang L; Delaney KH; Lucas AR
Journal
Biomedicines, Vol. 8, No. 10,
Publisher
MDPI
DOI
10.3390/biomedicines8100372
ISSN
2227-9059