Journal article
Thrombospondin-1/CD47 signaling modulates transmembrane cation conductance, survival, and deformability of human red blood cells
Abstract
BackgroundThrombospondin-1 (TSP-1), a Ca2+-binding trimeric glycoprotein secreted by multiple cell types, has been implicated in the pathophysiology of several clinical conditions. Signaling involving TSP-1, through its cognate receptor CD47, orchestrates a wide array of cellular functions including cytoskeletal organization, migration, cell-cell interaction, cell proliferation, autophagy, and apoptosis. In the present study, we investigated …
Authors
Bissinger R; Petkova-Kirova P; Mykhailova O; Oldenborg P-A; Novikova E; Donkor DA; Dietz T; Bhuyan AAM; Sheffield WP; Grau M
Journal
Cell Communication and Signaling, Vol. 18, No. 1,
Publisher
Springer Nature
Publication Date
December 2020
DOI
10.1186/s12964-020-00651-5
ISSN
1478-811X