Conference
Impact of Tisagenlecleucel Chimeric Antigen Receptor (CAR)-T Cell Therapy Product Attributes on Clinical Outcomes in Adults with Relapsed or Refractory Diffuse Large B-Cell Lymphoma (r/r DLBCL)
Abstract
Background: In the phase 2 JULIET trial, tisagenlecleucel, an anti-CD19 CAR-T cell therapy, demonstrated durable responses and manageable safety in adult patients (pts) with r/r DLBCL. Here, we examine the impact of key product cellular attributes of tisagenlecleucel on clinical outcomes.
Methods: JULIET is a single-arm, global, phase 2 trial of tisagenlecleucel in adult pts with r/r DLBCL. Samples from 115 tisagenlecleucel …
Authors
Bachanova V; Tam CS; Borchmann P; Jaeger U; McGuirk JP; Holte H; Waller EK; Jaglowski S; Bishop MR; Andreadis C
Volume
134
Publisher
American Society of Hematology
Publication Date
November 13, 2019
DOI
10.1182/blood-2019-128302
Conference proceedings
Blood
Issue
Supplement_1
ISSN
0006-4971