Journal article
Endothelin-1 axis fosters YAP-induced chemotherapy escape in ovarian cancer
Abstract
The majority of ovarian cancer (OC) patients recur with a platinum-resistant disease. OC cells activate adaptive resistance mechanisms that are only partially described. Here we show that OC cells can adapt to chemotherapy through a positive-feedback loop that favors chemoresistance. In platinum-resistant OC cells we document that the endothelin-1 (ET-1)/endothelin A receptor axis intercepts the YAP pathway. This cross-talk occurs through the …
Authors
Tocci P; Cianfrocca R; Sestito R; Rosanò L; Di Castro V; Blandino G; Bagnato A
Journal
Cancer Letters, Vol. 492, , pp. 84–95
Publisher
Elsevier
Publication Date
November 2020
DOI
10.1016/j.canlet.2020.08.026
ISSN
0304-3835