Maximum 24‐hour platelet count fall: Metric for improving the diagnosis of heparin‐induced thrombocytopenia among patients with intermediate probability 4Ts scores

BACKGROUND: Most patients with suspected heparin-induced thrombocytopenia (HIT) and an intermediate probability 4Ts score do not have HIT. We aimed to develop a metric based on the rate of platelet count fall to aid in discriminating HIT status among patients with an intermediate 4Ts score. METHODS: We derived a measure of the maximum 24-hour percentage decrease in platelet count (Fall_max ) in a cohort of patients with suspected HIT and an …