Journal article
Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction
Abstract
The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we report a multi-ancestry (N = 293,051) genome-wide association meta-analysis for the PR interval, discovering 202 loci of which 141 have not previously been reported. Variants at identified loci increase the percentage of heritability …
Authors
Ntalla I; Weng L-C; Cartwright JH; Hall AW; Sveinbjornsson G; Tucker NR; Choi SH; Chaffin MD; Roselli C; Barnes MR
Journal
Nature Communications, Vol. 11, No. 1,
Publisher
Springer Nature
DOI
10.1038/s41467-020-15706-x
ISSN
2041-1723