Journal article
TNF-alpha production by eosinophils in upper airways inflammation (nasal polyposis).
Abstract
TNF-alpha is a cytokine with a wide spectrum of proinflammatory activities. Nasal polyps (NP), which occur in association with allergic rhinitis and asthma, are characterized by a marked infiltration of activated eosinophils, epithelial damage, and varying degrees of stromal fibrosis. By using Southern blot analysis after a reverse transcription-PCR, we detected a signal specific for TNF-alpha mRNA in five of seven NP samples, but not in …
Authors
Finotto S; Ohno I; Marshall JS; Gauldie J; Denburg JA; Dolovich J; Clark DA; Jordana M
Journal
The Journal of Immunology, Vol. 153, No. 5, pp. 2278–2289
Publisher
Oxford University Press (OUP)
Publication Date
September 1, 1994
DOI
10.4049/jimmunol.153.5.2278
ISSN
0022-1767