Journal article
IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses.
Abstract
IL-6 is induced often together with the proinflammatory cytokines TNFalpha and IL-1 in many alarm conditions, and circulating IL-6 plays an important role in the induction of acute phase reactions. However, whether this endogenous IL-6 plays any additional pro- or antiinflammatory roles in local or systemic responses remains unclear. In this study, the role of IL-6 in acute inflammatory responses was investigated in animal models of endotoxic …
Authors
Xing Z; Gauldie J; Cox G; Baumann H; Jordana M; Lei XF; Achong MK
Journal
Journal of Clinical Investigation, Vol. 101, No. 2, pp. 311–320
Publisher
American Society for Clinical Investigation
Publication Date
January 15, 1998
DOI
10.1172/jci1368
ISSN
0021-9738