Journal article
Temporal–Spatial Analysis of the Immune Response in a Murine Model of Ovalbumin-Induced Airways Inflammation
Abstract
The objective of this study was to define phenotypic changes of antigen-presenting cells (APCs) and T cells in a murine model of antigen-induced airways inflammation that involves intraperitoneal sensitization with ovalbumin (OVA)/adjuvant followed by antigen aerosolization. We investigated the APC and T-cell compartments both after sensitization (primary immune response) and after challenge (secondary immune response) at the thoracic lymph …
Authors
Gajewska BU; Swirski FK; Alvarez D; Ritz SA; Goncharova S; Cundall M; Snider DP; Coyle AJ; Gutierrez-Ramos J-C; Stämpfli MR
Journal
American Journal of Respiratory Cell and Molecular Biology, Vol. 25, No. 3, pp. 326–334
Publisher
American Thoracic Society
Publication Date
September 1, 2001
DOI
10.1165/ajrcmb.25.3.4482
ISSN
1044-1549
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AerosolsAnimalsAntigen-Presenting CellsAntigens, CDB7-1 AntigenB7-2 AntigenBronchial Provocation TestsCytokinesDNA-Binding ProteinsDisease Models, AnimalFemaleFlow CytometryGATA3 Transcription FactorHistocompatibility Antigens Class IIInterleukin-1 Receptor-Like 1 ProteinLungLymph NodesMembrane GlycoproteinsMembrane ProteinsMiceMice, Inbred BALB COvalbuminPneumoniaProteinsReceptors, InterleukinSTAT6 Transcription FactorT-Lymphocyte SubsetsTrans-Activators