Journal article
Evaluation of Inducible Costimulator/B7-Related Protein-1 as a Therapeutic Target in a Murine Model of Allergic Airway Inflammation
Abstract
Given its primary role in the execution of T cell, and especially Th2, effector activity, the inducible costimulator (ICOS)/B7-related protein (RP)-1 costimulatory pathway is currently being heralded as a promising therapeutic target for immune-inflammatory disorders such as asthma. This study investigates the merits of ICOS blockade in a murine model of experimental asthma in which mice are sensitized to ovalbumin (OVA) through the respiratory …
Authors
Wiley RE; Goncharova S; Shea T; Johnson JR; Coyle AJ; Jordana M
Journal
American Journal of Respiratory Cell and Molecular Biology, Vol. 28, No. 6, pp. 722–730
Publisher
American Thoracic Society
Publication Date
6 2003
DOI
10.1165/rcmb.2002-0220oc
ISSN
1044-1549
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsAntibodiesAntigens, Differentiation, T-LymphocyteAsthmaB7-1 AntigenBronchoalveolar LavageCells, CulturedChemokine CCL11Chemokines, CCDesensitization, ImmunologicDisease Models, AnimalFemaleImmunoglobulin EInducible T-Cell Co-Stimulator LigandInducible T-Cell Co-Stimulator ProteinInflammationInterleukin-10Interleukin-13Interleukin-4Interleukin-5LungMiceMice, Inbred BALB COvalbuminSpleenTh1 CellsTh2 Cells