Journal article
Concurrent blockade of platelet-activating factor and histamine prevents life-threatening peanut-induced anaphylactic reactions
Abstract
BACKGROUND: Food anaphylaxis is an acute and life-threatening systemic allergic reaction. Fatality registries place peanut as the most common culprit of fatal and near-fatal reactions in North America. Because prophylaxis and treatment have advanced little in recent years, it is imperative to evaluate novel therapies.
OBJECTIVE: To investigate the impact of blocking mast cell mediators in a mouse model of peanut-induced anaphylaxis.
Authors
Arias K; Baig M; Colangelo M; Chu D; Walker T; Goncharova S; Coyle A; Vadas P; Waserman S; Jordana M
Journal
The Journal of Allergy and Clinical Immunology, Vol. 124, No. 2, pp. 307–314.e2
Publisher
Elsevier
Publication Date
August 2009
DOI
10.1016/j.jaci.2009.03.012
ISSN
0091-6749
Associated Experts
Fields of Research (FoR)
Sustainable Development Goals (SDG)
Medical Subject Headings (MeSH)
AllergensAnaphylaxisAnimalsArachisCholera ToxinCimetidineDisease Models, AnimalDrug Therapy, CombinationEnzyme InhibitorsFemaleHistamineHistamine AntagonistsHistamine H1 AntagonistsHydroxyureaImmunoglobulin EImmunoglobulin GLipoxygenase InhibitorsMiceMice, Inbred C57BLPeanut HypersensitivityPlatelet Membrane GlycoproteinsPyrilamineReceptors, G-Protein-CoupledReceptors, Histamine