Journal article
Pulmonary M. tuberculosis infection delays Th1 immunity via immunoadaptor DAP12-regulated IRAK-M and IL-10 expression in antigen-presenting cells
Abstract
Interaction of mycobacteria with the host leads to retarded expression of T helper cell type 1 (Th1) immunity in the lung. However, the immune mechanisms remain poorly understood. Using in vivo and in vitro models of Mycobacterium tuberculosis (M. tb) infection, we find the immunoadaptor DAP12 (DNAX-activating protein of 12 kDa) in antigen-presenting cells (APCs) to be critically involved in this process. Upon infection of APCs, DAP12 is …
Authors
Jeyanathan M; McCormick S; Lai R; Afkhami S; Shaler CR; Horvath CN; Damjanovic D; Zganiacz A; Barra N; Ashkar A
Journal
Mucosal Immunology, Vol. 7, No. 3, pp. 670–683
Publisher
Elsevier
Publication Date
5 2014
DOI
10.1038/mi.2013.86
ISSN
1933-0219
Associated Experts
Fields of Research (FoR)
Sustainable Development Goals (SDG)
Medical Subject Headings (MeSH)
Adaptor Proteins, Signal TransducingAnimalsAntigen PresentationAntigen-Presenting CellsCytokinesDisease Models, AnimalGene Expression RegulationInflammation MediatorsInterleukin-1 Receptor-Associated KinasesInterleukin-10LungLymphocyte ActivationMaleMiceMycobacterium tuberculosisNF-kappa BSignal TransductionTh1 CellsTuberculosis, Pulmonary