Journal article
Medulloblastoma stem cells: Modeling tumor heterogeneity
Abstract
Brain tumors represent the leading cause of childhood cancer mortality, with medulloblastoma (MB) being the most frequent malignant tumor. In this review we discuss the morphological and molecular heterogeneity of this malignant childhood brain tumor and how this key feature has implicated the presence of a MB stem cell. We focus on evidence from cerebellar development, histopathological and molecular subtypes of MB, the recent identification …
Authors
Manoranjan B; Venugopal C; McFarlane N; Doble BW; Dunn SE; Scheinemann K; Singh SK
Journal
Cancer Letters, Vol. 338, No. 1, pp. 23–31
Publisher
Elsevier
Publication Date
9 2013
DOI
10.1016/j.canlet.2012.07.010
ISSN
0304-3835