Journal article
Control of Centromere Localization of the MEI-S332 Cohesion Protection Protein
Abstract
In mitosis and meiosis, cohesion is maintained at the centromere until sister-chromatid separation. Drosophila MEI-S332 is essential for centromeric cohesion in meiosis and contributes to, though is not absolutely required for, cohesion in mitosis. It localizes specifically to centromeres in prometaphase and delocalizes at the metaphase-anaphase transition. In mei-S332 mutants, centromeric sister-chromatid cohesion is lost at anaphase I, giving …
Authors
Lee JY; Dej KJ; Lopez JM; Orr-Weaver TL
Journal
Current Biology, Vol. 14, No. 14, pp. 1277–1283
Publisher
Elsevier
Publication Date
July 2004
DOI
10.1016/j.cub.2004.07.023
ISSN
0960-9822
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsBlotting, WesternCell Cycle ProteinsCell DivisionCells, CulturedCentromereChromatidsChromosomal Proteins, Non-HistoneChromosome SegregationDNA PrimersDrosophilaDrosophila ProteinsEndopeptidasesFungal ProteinsGreen Fluorescent ProteinsHumansLuminescent ProteinsMicroscopy, FluorescenceMutagenesis, Site-DirectedNuclear ProteinsProtein Structure, TertiaryRNA InterferenceSeparaseTransfectionCohesins