Conference
Responder Interferon λ Genotypes Are Associated With Higher Risk of Liver Fibrosis in HIV–Hepatitis C Virus Coinfection
Abstract
BACKGROUND: Liver fibrosis progresses faster in individuals coinfected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV). Interferon λ3 (IFN-λ3) has both antiviral and proinflammatory properties. Genotypes at IFNL single-nucleotide proteins (SNPs; rs12979860CC and rs8099917TT) are linked to higher HCV clearance, potentially via rs8103142. We examined the relationship between IFN-λ genotypes and significant liver fibrosis in …
Authors
Moqueet N; Cooper C; Gill J; Hull M; Platt RW; Klein MB; Cohort FTCC-I; Cohen J; Conway B; Cooper C
Volume
214
Pagination
pp. 80-86
Publisher
Oxford University Press (OUP)
Publication Date
July 1, 2016
DOI
10.1093/infdis/jiw088
Conference proceedings
The Journal of Infectious Diseases
Issue
1
ISSN
0022-1899