Journal article
Systemic Sclerosis Immunoglobulin Induces Growth and a Pro-Fibrotic State in Vascular Smooth Muscle Cells through the Epidermal Growth Factor Receptor
Abstract
OBJECTIVE: It has been suggested that autoantibodies in systemic sclerosis (SSc) may induce the differentiation of cultured fibroblasts into myofibroblasts through platelet-derived growth factor receptor (PDGFR) activation. The present study aims to characterize the effects of SSc IgG on vascular smooth muscle cells (VSMCs) and to determine if stimulatory autoantibodies directed to the PDGFR can be detected, and whether they induce a …
Authors
Arts MR; Baron M; Chokr N; Fritzler MJ; Group TCSR; Servant MJ
Journal
PLOS ONE, Vol. 9, No. 6,
Publisher
Public Library of Science (PLoS)
DOI
10.1371/journal.pone.0100035
ISSN
1932-6203