Journal article
Danger, diversity and priming in innate antiviral immunity
Abstract
The prototypic response to viral infection involves the recognition of pathogen-associated molecular patterns (PAMPs) by pattern recognition receptors (PRRs), leading to the activation of transcription factors such as IRF3 and NFkB and production of type 1 IFN. While this response can lead to the induction of hundreds of IFN-stimulated genes (ISGs) and recruitment and activation of immune cells, such a comprehensive response is likely …
Authors
Collins SE; Mossman KL
Journal
Cytokine & Growth Factor Reviews, Vol. 25, No. 5, pp. 525–531
Publisher
Elsevier
Publication Date
10 2014
DOI
10.1016/j.cytogfr.2014.07.002
ISSN
1359-6101