Biomarkers of collagen turnover are related to annual change in FEV1 in patients with chronic obstructive pulmonary disease within the ECLIPSE study

Abstract

BackgroundChange in forced expiratory volume in one second (FEV1) is important for defining severity of chronic obstructive pulmonary disease (COPD). Serological neoepitope markers of collagen turnover may predict rate of change in FEV1.MethodsOne thousand COPD subjects from the observational, multicentre, three-year ECLIPSE (Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints) study (NCT00292552, trial registration in …

Authors

Leeming DJ; Byrjalsen I; Sand JMB; Bihlet AR; Lange P; The Evaluation of COPD Longitudinally to Identify Surrogate Endpoints (ECLIPSE) study investigators; Thal-Singer R; Miller BE; Karsdal MA; Vestbo J