A model of massive pulmonary embolism, development and characterization: The pre-clinical steps forward and details of the progress

Background: Massive pulmonary embolism (MPE) is in most cases an unpredictable, life-threatening lung injury. In order to test this shock and its natural sequence, MPE animal model was established. Based on previous models, discussed within the article framework, this model was designed to closely narrate clinical pulmonary embolism. Methods: MPE was induced by a single injection of minced radioactive blood thrombi into an internal jugular …