The cDNA Sequence of Human Endothelial Cell Multimerin A UNIQUE PROTEIN WITH RGDS, COILED-COIL, AND EPIDERMAL GROWTH FACTOR-LIKE DOMAINS AND A CARBOXYL TERMINUS SIMILAR TO THE GLOBULAR DOMAIN OF COMPLEMENT C1q AND COLLAGENS TYPE VIII AND X *

Multimerin is a massive, soluble protein found in platelets and in the endothelium of blood vessels. Multimerin is composed of varying sized, disulfide-linked multimers, the smallest of which is a homotrimer. Multimerin is a factor V/Va-binding protein and may function as a carrier protein for platelet factor V. The cDNA for human multimerin was isolated from lambda gt11 endothelial cell libraries using antibodies, and the isolated cDNA clones …