Journal article
Assembling the glycopeptide antibiotic scaffold: The biosynthesis of A47934 from Streptomyces toyocaensis NRRL15009
Abstract
The glycopeptide antibiotics vancomycin and teicoplanin are vital components of modern anti-infective chemotherapy exhibiting outstanding activity against Gram-positive pathogens including members of the genera Streptococcus, Staphylococcus, and Enterococcus. These antibiotics also provide fascinating examples of the chemical and associated biosynthetic complexity exploitable in the synthesis of natural products by actinomycetes group of …
Authors
Pootoolal J; Thomas MG; Marshall CG; Neu JM; Hubbard BK; Walsh CT; Wright GD
Journal
Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, No. 13, pp. 8962–8967
Publication Date
June 25, 2002
DOI
10.1073/pnas.102285099
ISSN
0027-8424