Journal article
Rifamycin antibiotic resistance by ADP-ribosylation: Structure and diversity of Arr
Abstract
The rifamycin antibiotic rifampin is important for the treatment of tuberculosis and infections caused by multidrug-resistant Staphylococcus aureus. Recent iterations of the rifampin core structure have resulted in new drugs and drug candidates for the treatment of a much broader range of infectious diseases. This expanded use of rifamycin antibiotics has the potential to select for increased resistance. One poorly characterized mechanism of …
Authors
Baysarowich J; Koteva K; Hughes DW; Ejim L; Griffiths E; Zhang K; Junop M; Wright GD
Journal
Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, No. 12, pp. 4886–4891
Publisher
Proceedings of the National Academy of Sciences
Publication Date
March 25, 2008
DOI
10.1073/pnas.0711939105
ISSN
0027-8424
Fields of Research (FoR)
Sustainable Development Goals (SDG)
Medical Subject Headings (MeSH)
ADP Ribose TransferasesAntibiotics, AntitubercularBacterial ProteinsCatalysisChromatography, High Pressure LiquidDrug Resistance, MicrobialEscherichia coliGenetic VariationKineticsMicrobial Sensitivity TestsMutationMycobacterium smegmatisProtein Structure, SecondaryRifampinStructural Homology, ProteinStructure-Activity Relationship