Journal article
Inhibition of WTA Synthesis Blocks the Cooperative Action of PBPs and Sensitizes MRSA to β‑Lactams
Abstract
Rising drug resistance is limiting treatment options for infections by methicillin-resistant Staphylococcus aureus (MRSA). Herein we provide new evidence that wall teichoic acid (WTA) biogenesis is a remarkable antibacterial target with the capacity to destabilize the cooperative action of penicillin-binding proteins (PBPs) that underlie β-lactam resistance in MRSA. Deletion of gene tarO, encoding the first step of WTA synthesis, resulted in …
Authors
Farha MA; Leung A; Sewell EW; D’Elia MA; Allison SE; Ejim L; Pereira PM; Pinho MG; Wright GD; Brown ED
Journal
ACS Chemical Biology, Vol. 8, No. 1, pp. 226–233
Publisher
American Chemical Society (ACS)
Publication Date
January 18, 2013
DOI
10.1021/cb300413m
ISSN
1554-8929