Journal article
A Cryptic Polyene Biosynthetic Gene Cluster in Streptomyces calvus Is Expressed upon Complementation with a Functional bldA Gene
Abstract
Streptomyces calvus is best known as the producer of the fluorinated natural product nucleocidin. This strain of Streptomycetes is also unusual for displaying a "bald" phenotype that is deficient in the formation of aerial mycelium and spores. Genome sequencing of this organism revealed a point mutation in the bldA gene that is predicted to encode a misfolded Leu-tRNA(UUA) molecule. Complementation of S. calvus with a correct copy of bldA …
Authors
Kalan L; Gessner A; Thaker MN; Waglechner N; Zhu X; Szawiola A; Bechthold A; Wright GD; Zechel DL
Journal
Cell Chemical Biology, Vol. 20, No. 10, pp. 1214–1224
Publisher
Elsevier
Publication Date
10 2013
DOI
10.1016/j.chembiol.2013.09.006
ISSN
2451-9456