Journal article
Cholinotrophic basal forebrain system alterations in 3xTg-AD transgenic mice
Abstract
The cholinotrophic system, which is dependent upon nerve growth factor and its receptors for survival, is selectively vulnerable in Alzheimer's disease (AD). But, virtually nothing is known about how this deficit develops in relation to the hallmark lesions of this disease, amyloid plaques and tau containing neurofibrillary tangles. The vast majority of transgenic models of AD used to evaluate the effect of beta amyloid (Aβ) deposition upon the …
Authors
Perez SE; He B; Muhammad N; Oh K-J; Fahnestock M; Ikonomovic MD; Mufson EJ
Journal
Neurobiology of Disease, Vol. 41, No. 2, pp. 338–352
Publisher
Elsevier
Publication Date
2 2011
DOI
10.1016/j.nbd.2010.10.002
ISSN
0969-9961