Journal article
Tau downregulates BDNF expression in animal and cellular models of Alzheimer's disease
Abstract
In Alzheimer's disease, soluble tau accumulates and deposits as neurofibrillary tangles (NFTs). However, a precise toxic mechanism of tau is not well understood. We hypothesized that overexpression of wild-type tau downregulates brain-derived neurotrophic factor (BDNF), a neurotrophic peptide essential for learning and memory. Two transgenic mouse models of human tau expression and human tau (hTau40)-transfected human neuroblastoma (SH-SY5Y) …
Authors
Rosa E; Mahendram S; Ke YD; Ittner LM; Ginsberg SD; Fahnestock M
Journal
Neurobiology of Aging, Vol. 48, , pp. 135–142
Publisher
Elsevier
Publication Date
12 2016
DOI
10.1016/j.neurobiolaging.2016.08.020
ISSN
0197-4580